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GAPDH

Die Glycerinaldehyd-3-phosphat-Dehydrogenase (GAPDH) ist ein Enzym der Glycolyse und daher unentbehrlich für alle Lebewesen. Sie katalysiert die Umwandlung von Glycerinaldehyd-3-phosphat zu 1,3-Bisphosphoglycerat Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) (EC 1.2.1.12) is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of.

Glycerinaldehyd-3-phosphat-Dehydrogenase, kurz GAPDH, ist ein Enzym, das in der Glykolyse die Dehydrierung des Glycerinaldehyd-3-phosphats zu 1,3-Bisphosphoglycerat katalysiert, wobei auch eine Phosphorylierung stattfindet. 2 Biochemie Glycerinaldehyd-3-phosphat bildet mit der GAPDH ein kovalentes Intermediat GAPDH expression is deregulated during melanoma progression. Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase. MZF-1 binds to and positively regulates the GAPDH promoter, indicating a role for GAPDH in calcitriol-mediated signaling Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase. Overexpression of GAPDH significantly augmented Mst1 mediated apoptosis, whereas knockdown of GAPDH markedly attenuated Mst1 activation and cardiomyocyte apoptosis

Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate GAPDH is commonly used by biological researchers as a loading control for western blot and as a control for qPCR, because the GAPDH gene is often stably and constitutively expressed at high levels in many tissues and cells, which is considered as a housekeeping gene GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimer's diseases (4,5). Barber, R.D. et al. (2005) Physiol Genomics 21, 389-95. Hara, M.R. and Snyder, S.H. Cell Mol Neurobiol (2006) 26, 527-38. Zheng, L. et al. (2003) Cell 114, 255-66. Bae, B.I. et al. (2006) Proc Natl Acad Sci USA 103, 3405-9. Wang, Q. et al. (2005) FASEB J. 19, 869-71. Pathways. Full length native protein (purified) corresponding to Human GAPDH

Glycerinaldehyd-3-phosphat-Dehydrogenase - Wikipedi

  1. GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) is a Protein Coding gene. Diseases associated with GAPDH include Aging and Schistosomiasis. Among its related pathways are Glucose metabolism and Cori Cycle. Gene Ontology (GO) annotations related to this gene include identical protein binding and NAD binding
  2. The GAPDH (glyceraldehyde-3-phospha te dehydrogenase) gene is mapped to human chromosome 12p13.3 and encodes a tetramer containing identical chains. The enzyme is commonly known as glycolytic enzyme and contains a binding site for NAD + (nicotinamide adenine diphosphate) and glyceraldehyde-3-phosphat e
  3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), also called uracil DNA glycosylase, catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism
  4. g western blots

GAPDH is a 146 kDa tetramer composed of four 30-40 kDa subunits. There is no cross-reaction with GAPDH from yeast. Preliminary data indicates that the GAPDH antibody- loading control ab8245 recognizes the monomer (36 kDa) and also the dimer forms of GAPDH, but not the tetrameric form of the protein GAPDH wird in fast allen Geweben auf hohem Level konstitutiv exprimiert. Es dient daher häufig als Ladekontrolle bei Northern- bzw. Western Blots. Achtung: Einige physiologische Faktoren, wie Hypoxie und Diabetes sowie einige Krebsarten führen zu einer gesteigerten GAPDH-Expression in bestimmten Zelltypen. Tubulin . Tubulin Ladekontroll-Antikörper Molekulargewicht: 55 kD Geeignet für. GAPDH is responsible for catalyzing the phosphorylation of glyceraldehyde-3-phosphate into D-glycerate-1,3-biphosphate. While this function of GAPDH is considered its primary function, GAPDH is also involved, even critical, in other cell functions, some of which are still being studied. Recent studies have suggested that GAPDH

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Glyceraldehyde 3-phosphate dehydrogenase - Wikipedi

The Applied Biosystems TaqMan GAPDH Control Reagents kit provides components for using human GAPDH as a normalization control in your real-time PCR reactions. The kit includes human control RNA, GAPDH TaqMan probe (JOE dye-labeled probe), and GAPDH primers. You can use either DNA or RNA as a targe Summary: The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains

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To investigate the value of GAPDH as a housekeeping gene in human tissues, the expression of GAPDH mRNA was measured in a panel of 72 different pathologically normal human tissue types. Measurements were obtained from 371,088 multiplexed, quantitative real-time RT-PCRs with specific target genes. Significant differences in the expression levels of GAPDH mRNA were observed between tissue types. Overall reliability score for the subcellular location (s) of the protein (s) in human cells, and summary of the antibodies used for immunostainings. Read more. Reliability scorei. Overall gene reliability score for the subcellular location (s) of the encoded protein (s) GAPDH antibody recognizes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein, a glycolytic enzyme of ~37 kDa that forms a tetramer. Because of its widespread expression, GAPDH is commonly used as an internal control for various protein assays, particularly western blot, to validate both the amount and quality of the loaded lysate samples The gene view histogram is a graphical view of mutations across GAPDH. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left

Glycerinaldehyd-3-phosphat-Dehydrogenase - DocCheck Flexiko

Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody, clone 6C5 is a well published and extensively characterized monoclonal antibody. This purified mAb detects Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) & has been published & validated for use in ELISA, IP, IC, IF, IH & WB. - Find MSDS or SDS, a COA, data sheets and more information Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate

Although increased GAPDH gene expression and enzymatic function is associated with cell proliferation and tumourigenesis, conditions such as oxidative stress impair GAPDH catalytic activity and lead to cellular aging and apoptosis. The mechanism(s) underlying the effects of GAPDH on cellular proliferation remains unclear, yet much evidence has been accrued that demonstrates a variety of. VWA5A (11q24.2) / GAPDH (12p13.31) ZNF638 (2p13.2) / GAPDH (12p13.31) ZNF836 (19q13.41) / GAPDH (12p13.31) Note: Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute: DNA/RNA : Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ] t(3;12)(q27;p13) GAPDH/BCL6: Other Solid tumors implicated. The Applied Biosystems® Human GAPD (GAPDH) Endogenous Control (FAM™ Dye ⁄ MGB Probe, Non-Primer Limited) is intended as an endogenous control. It allows relative gene expression quantification in cDNA samples when used with other TaqMan® Gene Expression Assays. Probe is labeled with 6FAM™ dye - MGB and the primers are not limited GAPDH, Abk. für Glycerinaldehyd-3-phosphat-Dehydrogenas

Human GAPDH is a 3.8-kb gene encoding the enzyme, glyceraldehyde 3-phosphate dehydrogenase. GAPDH is actively expressed in most human cells and tissues, and is considered a housekeeping gene. The gene is often used as a loading control for various molecular experiments, including qPCR. Visit the supplier page for more primer information GAPDH wird in fast allen Geweben auf hohem Level konstitutiv exprimiert. Es dient daher häufig als Ladekontrolle bei Northern- bzw GAPDH is associated with 1 reactions in 1 different subsystems: Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome. Provided by metabolicatlas.org: Pathway / Subsystem Compartments # proteins # metabolites # reactions for this protein; Glycolysis / Gluconeogenesis: Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome: 81: 49:

Sie ist ein biochemischer Abbauweg, der in mehreren Schritten ein Molekül Glucose in zwei Moleküle Pyruvat umwandelt. 2 Hintergrund Die Glykolyse ist der einzige metabolische Weg, den praktisch alle modernen Organismen gemein haben, was auf eine sehr frühe Entstehung hinweist GAPDH is one of the most common housekeeping genes and is often used to normalize gene expression data. The data presented here show that there are significant differences in the levels of GAPDH mRNA expression across the comprehensive panel of tissues studied, with a maximum difference between the highest and lowest expression of 15-fold. This is consistent with the data presented by. Die Glucose-6-phosphat-Dehydrogenase (G6PD; EC 1.1.1.49) ist ein Enzym mit einer molaren Masse von maximal 59.289 Dalton (Da), das 249 bis 515 Aminosäuren umfasst und im Raum ein Homodimer oder Homotetramer bildet. Sie gehört zur Enzymfamilie der Oxidoreduktasen und bildet eine eigene Unterfamilie der Glucose-6-phosphat-Dehydrogenasen. G6PD existiert in zwei Isoformen, einer kurzen und einer. Housekeeping genes are typically constitutive genes that are required for the maintenance of basal cellular functions that are essential for the existence of a cell, regardless of its specific role in the tissue or organism. Thus, they are expressed in all cells of an organism under normal and patho-physiological conditions, irrespective of tissue type, developmental stage, cell cycle state.

GAPDH antibody from EMD Millipore. GAPD. Western blot Recommended by provider ELISA Recommended by provider Immunocytochemistry Recommended by provider Immunoprecipitation Recommended by provider Immunohistochemistry Recommended by provider. Provider product page for MAB374. Antibody data. Antibody Data; Knockdown Reagents [0] References [72] Comments [0] Validations [0] Submit Validation data. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies GAPDH (36 kDa) is integral for glycolysis and plays many roles in nuclear function; such as transcription regulation and apoptosis. The stable and ubiquitous expression of GAPDH also make it a suitable loading control for many experiments. When using GAPDH as a loading control, it is important to keep in mind that its expression level does vary between tissues The GAPDH PCR module is an integral component of the Cloning and Sequencing Explorer Series. You can either use this module in conjunction with the electrophoresis module to visualize PCR results or purchase the module separately as a shorter stand-alone PCR laboratory activity to demonstrate applications of PCR in real research Anti-GAPDH Mouse mAb (6C5) Anti-GAPDH, mouse monoclonal, clone 6C5, recognizes ~146 kDa GAPDH protein under non-reducing conditions & 36 kDa monomers under reducing conditions. It is validated for use in ELISA, WB, and IHC. - Find MSDS or SDS, a COA, data sheets and more information

GAPDH glyceraldehyde-3-phosphate dehydrogenase [ (human)

  1. ed. A plot of deter
  2. Gapdh (Myc-DDK-tagged) - Mouse glyceraldehyde-3-phosphate dehydrogenase (cDNA clone MGC:107018 IMAGE:1067416) 10 ug; USD 206.00. Add To Cart. MR204934. Gapdh (Myc-DDK-tagged) - Mouse glyceraldehyde-3-phosphate dehydrogenase (Gapdh) 10 ug; USD 329.00. Add To Cart . Customer Reviews Loading... *Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen.
  3. Maus Monoklonal GAPDH Antikörper für DB, ISt, ELISA, WB. Publiziert in 3 Pubmed Referenzen. Order anti-GAPDH Antikörper ABIN559691

Gapdh glyceraldehyde-3-phosphate dehydrogenase [ (house

Die Applied Biosystems™ endogene Kontrolle für GAPD (GAPDH) (FAM™⁄MGB-Sonde, ohne Primerbegrenzung), Maus, ist als endogene Kontrolle vorgesehen. Sie ermöglicht die relative Quantifizierung der Genexpression in cDNA-Proben unter Verwendung anderer Assays zur Bestimmung der Genexpression. Die MGM-Sonde wird mit 6FAM™ Farbstoff markiert, und die Primer sind nicht begrenzt. Kann für. GAPDH can interact with proteins participating in DNA repair, such as APE1, PARP1, HMGB1, and HMGB2. In this review, the functions of GAPDH associated with DNA repair are discussed in detail. Title: Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in DNA Repair. GAPDH may act as a chaperone in heme transfer to downstream area Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme involved in glycolysis and shown, particularly in animal cells, to play additional roles in several unrelated non-metabolic processes such as control of gene expression and apoptosis. This functional versatility is regulated, in part at least, by redox post-translational modifications that alter GAPDH catalytic activity. In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may.

Glycolysis - WikipediaIdentification, prevalence and pathogenicity ofCytokeratin 10-specific Antibody 16855-1-AP | Proteintech

Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or, less commonly, as G3PDH) (EC 1.2.1.12) is an enzyme of ~37 kDa that plays an important role in glycolysis. GAPDH is a popular housekeeping stan­dard used in gene expression studies. Many researchers are not aware, however, of the difficulty of using this mRNA as a reference in. GAPDH is S-sulfurated by polysulfides at Cys 156, not active site Cys 152.. S-sulfuration of GAPDH at Cys 156 causes a decrease in enzymatic activity.NaSH and polysulfides can restore the activity of glutathione-oxidized GAPDH. • S-sulfuration of Cys 152 using a C156S mutant decreases enzymatic activity.Polysulfides are a stronger S-sulfurating agent than NaSH

GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Homo

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a 36-40 kDa member of the GAPDH family of enzymes. It is a widely expressed heterotetramer that is found in both the nucleus and cytoplasm. Although GAPDH was initially identified as a glycolytic enzyme that converted G3P into 1,3 diphosphoglycerate, it is now recognized to participate in no less than endocytosis, membrane fusion, vesicular. GAPDH catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Besides functioning as a glycolytic enzyme in cytoplasm, GAPDH has function in intracellular processes such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication and DNA repair. GAPDH catalyzes a vital energy.

GAPDH Loading Control OriGen

GAPDH (14C10) Rabbit mAb Cell Signaling Technolog

Goat anti Human GAPDH antibody recognizes an epitope within the C-terminal (CT) region of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a ~36 kDa multifunctional protein whose main function is to catalyse the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, in conjunction with inorganic phosphate and nicotinamide adenine dinucleotide (NAD) GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Synonyms: glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, G3PD, GAPD, HGNC.

Anti-GAPDH antibody - Loading Control (ab9485) Abca

GAPDH Gene - GeneCards G3P Protein G3P Antibod

GAPDH promoter (Ubiquitous) in pDRIVE expression plasmid. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a catalytic enzyme involved in glycolysis. The GAPDH gene is constitutively expressed at high levels in almost all tissues. However, the molecular mechanism which sustains high-level expression of this 'housekeeping' enzyme is still unclear. The expression of GAPDH can be induced. However, GAPDH spike RNA level was stable in its amplification at different kinds of stresses. So it can be an alternative for housekeeping gene due to its stability at these different conditions. qPCR is a robust technique which quantifies the expressions of target genes in relation to reference genes. Stresses such as virus infection or heat shock change expressions of many cellular genes. GAP-Umbau: Das Enzym Glycerinaldehyd-3-phosphat-Dehydrogenase (GAPDH) katalysiert den Umbau von GAP zu 1,3-Bisphosphoglycerat (1,3BPG). Gleichzeitig kommt es zur Reduktion von NAD+ zu NADH. Gleichzeitig kommt es zur Reduktion von NAD+ zu NADH GAPDH catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate during glycolysis as well as the reverse reaction in gluconeogenesis. β-actin is one of the cytoskeletal actins that are involved in cell motility, structure and integrity [ 18, 25 ] Background: GAPDH. GAPDH (Glyceraldehyde-3-phosphate Dehydrogenase) is a relatively stable enzyme involved in the second phase of glycolysis. It is generally thought to be present at a constant level in cells, regardless (in most cases) of experimental treatment or technical procedure. For this reason, measurement of GAPDH is generally used as an internal control for experimental error

Plasmid sgRNA 1 GAPDH from Dr. Bo Feng's lab contains the insert SgRNA and is published in Nucleic Acids Res. 2016 May 19;44(9):e85. doi: 10.1093/nar/gkw064. Epub 2016 Feb 4. This plasmid is available through Addgene Gapdh: Name: glyceraldehyde-3-phosphate dehydrogenase: RGD ID: 2661: Description: Exhibits several functions, including glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding activity; and peptidyl-cysteine S-nitrosylase activity. Involved in several processes, including gluconeogenesis; negative regulation of vascular associated smooth muscle cell apoptotic process; and peptidyl-cysteine S-trans-nitrosylation. Localizes to cytosol; microtubule. Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an important enzyme for energy metabolism and the production of ATP and pyruvate through anaerobic glycolysis in the cytoplasm. 2. Recent studies have shown that GAPDH has multiple functions independent of its role in energy metabolism

GAPDH antibody Gapdh Antibody Sigma-Aldric

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) represents a universally expressed reference gene that has many biological roles in addition to its function in glycolysis. A GAPDH assay has been developed for the accurate normalization of feline messenger RNA (mRNA) expression [ 10 Kornberg et al. found that DMF and its metabolite, monomethyl fumarate, succinate the glycolytic enzyme GAPDH (see the Perspective by Matsushita and Pearce). After DMF treatment, GAPDH was inactivated, and aerobic glycolysis was down-regulated in both myeloid and lymphoid cells. This resulted in down-modulated immune responses because inflammatory immune-cell subsets require aerobic glycolysis. Thus, metabolism can serve as a viable therapeutic target in autoimmune disease. Science , this. metabolism. While GAPDH has long been recognized as playing an integral role in glycolysis, additional functions of GAPDH include acting as an uricil DNA glycosylase, activating transcription, binding RNA and involvement in nuclear RNA export, DNA replication and DNA repair. Expression of GAPDH is upregulated in liver, lung and prostate cancers. GAPDH translocates t Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions

Wofür steht GAPDH im Text In Summe ist GAPDH ein Akronym oder Abkürzungswort, das in einfacher Sprache definiert ist. Diese Seite zeigt, wie GAPDH in Messaging- und Chat-Foren verwendet wird, zusätzlich zu Social-Networking-Software wie VK, Instagram, Whatsapp und Snapchat. Aus der obigen Tabelle können Sie alle Bedeutungen von GAPDH anzeigen: einige sind pädagogische Begriffe, die anderen sind medizinische Begriffe und sogar Computerbegriffe. Wenn Sie eine andere Definition von GAPDH. GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase; EC 1.2.1.12) catalyzes the conversion of Glyceraldehyde-3-Phosphate (GAP) to 1, 3-Bisphosphate Glycerate (BPG) and plays a key role in glycolysis. The enzyme is involved in cellular processes such as apoptosis, membrane trafficking, iron metabolism and nuclear translocation. GAPDH (housekeeping gene) expression is stable and constitutive. Deregulation of GAPDH activity is associated with abnormal cell proliferation and carcinogenesis. Accurate.

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GAPDH Antibody (6C5) SCBT - Santa Cruz Biotechnolog

PrimePCR™ SYBR® Green Assay: GAPDH, Human glyceraldehyde-3-phosphate dehydrogenase Assay Type: SYBR® Green Assay Design: exonic Application: Gene Expression Unique Assay ID: qHsaCED0038674 Info: Same primer pair as used in probe assay qHsaCEP004139 Home > Protein > GAPDH New Protein Search: Glyceraldehyde-3-phosphate dehydrogenase Show on y-axis -References (HTP + LTP) References (LTP) References (HTP) log2 Transformation. Filter PTM sites. Minimum 5 References Add Disease Variants. Somatic Cancer Mutations Germline Disease SNPs. GAPDH. A gene on chromosome 12p13 that encodes glyceraldehyde-3-phosphate dehydrogenase, which has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities. It catalyses the reversible. oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide, an important. GAPDH has been shown to be involved in membrane transport and membrane fusion, microtubule assembly, nuclear RNA export, protein phosphotransferase/kinase reactions, the translational control of gene expression, DNA replication, and DNA repair. 24 Indeed, these functions of β-actin and GAPDH determine the need, not only for their expression in every cell, but also confer the requirement for tightly regulated expression

Transcription vs Translation - Difference and Comparison

Google Scholar provides a simple way to broadly search for scholarly literature. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions Rabbit anti GAPDH (N-Terminal) antibody recognizes human glyceraldehyde 3-phosphate dehydrogenase (GAPDH). GAPDH is a major glycolytic enzyme within the cytosol, which is also involved in a number of intracellular processes including membrane fusion, microtubule bundling, phosphotransferase, DNA replication and DNA repair Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the phosphorylation of glyceraldehyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue (1), GAPDH is thought to be a constitutively expressed housekeeping protein GAPDH glyceraldehyde-3-phosphate dehydrogenase. Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S. Featured Anti-GAPDH Mouse Monoclonal Antibody (2B5), specially designed for your immunoassay as internal control.,GAPDH; GAPD; CDABP0047; OK/SW-cl.12; Glyceraldehyde-3-phosphate dehydrogenase; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH,Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH) is an enzyme of 37kDa that catalyzes the sixth step of glycolysis. The use of GAPDH in the studies with clinical samples of cervical human tissues HPV-positive appeared as a reliable strategy for the normalization in qRT-PCR using the program NormFinder (Shen et al. 2010). On the other hand, GAPDH was not suitable as an internal control in rabbit tissues (Deindl et al. 2002) and in nucleated human blood cells (Bustin et al. 1999)

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